| Rang | Name | Verein | Tore |
|---|---|---|---|
| 1 | Edin Dzeko | VfL Wolfsburg | 22 |
| 2 | Stefan Kießling | Bayer Leverkusen | 21 |
| 3 | Lucas Barrios | Borussia Dortmund | 19 |
| 4 | Kevin Kuranyi | FC Schalke 04 | 18 |
| 5 | Claudio Pizarro | Werder Bremen | 16 |
| Arjen Robben | Bayern München | 16 | |
| 7 | Cacau | VfB Stuttgart | 13 |
| Thomas Müller | Bayern München | 13 | |
| 9 | Albert Bunjaku | 1. FC Nürnberg | 12 |
| Eren Derdiyok | Bayer Leverkusen | 12 | |
| Vedad Ibisevic | 1899 Hoffenheim | 12 | |
| 12 | Grafite | VfL Wolfsburg | 11 |
| Ivica Olic | Bayern München | 11 | |
| 14 | Aristide Bancé | 1. FSV Mainz 05 | 10 |
| Mario Gomez | Bayern München | 10 | |
| Ciprian Marica | VfB Stuttgart | 10 | |
| Alexander Meier | Eintracht Frankfurt | 10 | |
| Zvjezdan Misimovic | VfL Wolfsburg | 10 | |
| Adrian Ramos | Hertha BSC | 10 |
Stand vom 8.5.2010